Beta-Lactamases Producing Escherichia coli and Klebsiella pneumoniae Isolated from Cattle Farms and Raw Beef in North-West Province, South Africa Kotsoana Peter Montso,1 Sicelo Beauty Dlamini,1 Ajay Kumar,2 and Collins Njie Ateba 1 1 Department of Microbiology, Faculty of Natural and Agricultural Sciences, North-West University, Int J Gen Med. Klebsiella [kleb−see−ell−uh] is a type of Gram-negative bacteria that can cause different types of healthcare-associated infections, including pneumonia, bloodstream infections, wound or surgical site infections, and meningitis. We generated an active antimicrobial peptide from a previously inactive parental peptide and characterized the interactions of these peptides with K. pneumoniae and its capsule. Udders become infected with coliform Sex differences have been described in a number of pulmonary diseases. Introduction Extended-spectrum beta-lactamases (ESBLs) are enzymes produced by Gram-nega- A protracted outbreak of New Delhi metallo-beta-lactamase (NDM)-producing carbapenem-resistant Klebsiella pneumoniae , started in Tuscany, Italy, in November 2018 and continued in 2020 and through 2021. For a subset of the patients (n=139) molecular analysis was performed on Klebsiella pneumoniae is a critical multidrug-resistant (MDR) bacterium in humans responsible for numerous hospital infections linked to high morbidity and mortality since treatment options are limited (Navon-Venezia et al. Klebsiella species are Gram-negative coliform bacteria. Overall, the most concerning trends in Europe in 2013 were related to the occurrence of resistance in gram-negative bacteria ( Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Acinetobacter species). Characterization was done by PCR and sequencing for bla(VIM), bla(IMP), bla(NDM), bla(OXA), bla(KPC), and … Antibiotic resistance is increasing among urinary pathogens, resulting in worse clinical and economic outcomes. Another explanation for these differences is related to the organism. There were no significant issues regarding species identification. For the tested K. pneumoniae isolated form short-stay ICU patients, all of the simulated IMP regimens reached ≥80% and 50–82% CFRs based on targets of 40% and 100% ƒT>MIC, respectively. Hypervirulent Klebsiella pneumoniae (hvKp) has emerged as a concerning global pathogen. The phenotypic and genotypic characteristics of K. pneumoniae in retail foods have not been thoroughly investigated in China. This study was conducted to assess the occurrence and nature of extended-spectrum beta lactamase (ESBL) producing Escherichia coli and Klebsiella pneumoniae isolates from patients who presented with urinary tract infection at Federal Teaching Hospital Gombe. AU - Lin, Michael Y. Extended spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae remain a critical clinical concern worldwide. Yet direct evidence that this happens in vivo is lacking. and E. coli cause the most severe clinical cases, with greater milk loss and an average cost of more than $221.03 per case (11). Klebsiella pneumoniae (KP) is a significant bloodstream pathogen resulting in major treatment and cost challenges for health institutions [].There is little data on children from Africa where the effects of socioeconomic inequalities and inadequate healthcare delivery remain challenging and influence the outcome of infectious diseases. ... Cholera - Vibrio cholerae Pneumonia - Streptococcus pneumoniae etc. Klebsiella pneumoniae can be broadly classified into two subtypes; classical Klebsiella pneumoniae (cKp) and non-classical Klebsiella pneumoniae (ncKp). This is called “resistant.” Increasingly, Klebsiella has been found to be resistant to the class of antibiotics known as carbapenems. We analysed factors associated with antibiotic-resistant bacteria (ARB) in patients hospitalized for urinary tract infection, using the comprehensive French national claims database. AU - Lyles-Banks, Rosie D. AU - Lolans, Karen. These results emphasize the importance of Gram-negative bacteria, particularly K. pneumoniae and P. aeruginosa, as major causes of pneumonia among the elderly in contrast to other reports, Streptococcus pneumoniae is a common cause of pneumonia among elderly individuals worldwide. Most of the identified bacterial species were affected by copper modified zeolites, although Serratia marcescens presented the highest sensitivity and Klebsiella pneumoniae the greatest resistance. Table 1. Klebsiella Pneumoniae Infection Drug Report 2021 mainly includes sales, revenue, trade, competition, investment, forecast and marketing of … Klebsiella pneumoniae causes only a small percentage of all pneumonias. In Spain, the incidence of carbapenem-resistant Klebsiella pneumoniae (CR-Kp) remains especially worrisome, showing a significant increasing trend from 2015 to 2019 . It has been a known human pathogen since it was first isolated in the late nineteenth century by Edwin Klebs. The objective of this study was to characterize K. pneumoniae isolates through … 2017). In the United States, Klebsiella pneumoniae and Klebsiella oxytoca are the two strains responsible for most human illnesses. Klebsiella pneumoniae, a common gut bacteria, causes problems when it moves outside the gut and causes infection. Klebsiella pneumoniae K. pneumoniae in . Data collection was performed using an instrument composed of sociodemographic data, clinical and … and 20% in Klebsiella pneumoniae. Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Bacillus sp., were obtained from bacteriology laboratory and was sub-cultured on ... an economic importance. To test the importance of LpxO-dependent lipid A modification in K. pneumoniae virulence, we evaluated the ability of 52145-ΔlpxO to cause pneumonia. Klebsiella pneumoniae is a bacterium that normally lives inside human intestines, where it doesn't cause disease.. However, it may also commonly cause pneumonia, an infection of the lungs that produces symptoms including fever, chills, coughing, shortness of breath, fatigue, and a sense of feeling run down. This work aimed to improve food safety in Benin. 30. Originally named Friedlander's bacillus, it was not until 1886 when the bacterium garnered the name Klebsiella. 2.7. But if K. pneumoniae gets into other areas of … The purpose of this study was to determine whether ozone exposure differentially affects: 1) survival of male and female mice infected with Klebsiella pneumoniae, and 2) … Antibiotic Resistance of Klebsiella pneumoniae Siderophore profiles found in Klebsiella pneumoniae isolates from both environmental and mastitis origin classified as resistant or sensitive to dry cow secretion (DCS) and non-immune bovine serum (NIBS)*. As of 21 October 2019, 17 patients in three hospitals and one rehabilitation clinic in Mecklenburg-West Pomerania in north-east Germany have been affected. Klebsiella pneumoniae is a gram-negative, opportunistic pathogen, and a common cause of healthcare-associated infections such as pneumonia, septicemia, and urinary tract infection. Germany has reported an outbreak of carbapenemase-producing (NDM-1 and OXA-48) and colistin-resistant Klebsiella pneumoniae sequence type (ST) 307. Klebsiella pneumoniae is a gram-negative, encapsulated, non-motile … ABR in ESKAPE organisms is usually associated with significant higher morbidity, mortality, as well as economic burden. Jamshid Razmyar. However, it is not clear why K. pneumoniae liver abscesses have this ethnic and geographic distribution. The aim of the present study was to examine the impact of an enhanced infection control program on the containment of CP-Kp in a haematology unit where the incidence of CP-Kp infections was high. An outbreak of yolk sac infection and dead-in-shell mortality in common canary (Serinus canaria) caused by Klebsiella pneumoniae. ABSTRACT Objective: To estimate the direct medical costs of drug therapy of Klebsiella pneumoniae carbapenemase (KPC) infection patients in hospital-based context. Klebsiella pneumoniae is not only a major hospital-acquired pathogen but also an important food-borne pathogen that can cause septicaemia, liver abscesses, and diarrhea in humans. T1 - The importance of long-term acute care hospitals in the regional epidemiology of klebsiella pneumoniae carbapenemase-producing enterobacteriaceae. Klebsiella pneumoniae was the most frequent pathogen in PLA (43.2% [16/37], 95% CI 27.1–60.5%). Klebsiella is a significant cause of healthcare-associated infections (HAIs). The economic costs of long-term sepsis- ... importance in sepsis prognosis. bacteria, such as Klebsiella spp., Escherichia coli, Pseudomonas spp., and Pasteurella spp. A short summary of this paper. However, the finding that Klebsiella pneumoniae were predominately recovered from diarrheic goats in the present study may be an indication for their importance in diarrheic goats as causative agent for diarrhea in the study area. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock. pneumoniae was considered an important cause of community-acquired pneumonia; however, in the last decade K. pneumoniae accounted for less than 1% of cases of pneumonia requiring hospitalization in North America. Infections with K. pneumoniae are usually hospital-acquired and occur primarily in patients with impaired host defenses. Using standard biochemical and serological techniques, the authors investigated a total of 213 strains of Klehsiella pneumoniae, which had been isolated from various clinical sources at the Mayo clinic and affiliated hospitals, during the period January 1970 to March 1970. anybody knows which antibiotic is used to treat klebsiella? Besides that, the presence of ESBL-producing strain has been reported in Saudi Arabia. In an urgent inquiry in ECDC’s Epidemic Intelligence Information System (EPIS) Antimicrobial Resistance and Healthcare-Associated Infections (AMR-HAI) platform, Ireland reported the isolation of hypervirulent Klebsiella pneumoniae (hvKp) ST23, from diagnostic samples and from rectal or faecal samples collected for the surveillance of carriage of carbapenemase-producing … Hospitalized urinary tract infections were identified from 2015 to 2017. Infections occur most frequently in hospitalised or immunocompromised patients and are treated with antimicrobials. Most importantly, the emergence of carbapenem-resistant Klebsiella pneumoniae is a global health concern and is listed by the World Health Organization (WHO) as a critical priority. Diabetes mellitus (DM) is a well-established risk factor for KPLA. IMPORTANCE The rapid development of the biodiesel industry has led to tremendous crude glycerol generation. AU - Petrak, Russell. Learn about its symptoms and treatment. However, the impact of ozone exposure followed by pneumonia infection on sex-related survival and macrophage function have not been reported. To understand the regional emergence and transmission dynamics over time, we collected and sequenced the genomes of 117 extensively drug-resistant, NDM-producing K. pneumoniae … Genetic susceptibility, socio-economic factors and geographic variance of specific K. pneumoniae serotypes may be contributing factors. Bacterial Proteins. During October 1–December 30, 2015, an outbreak of Klebsiella pneumoniae containing an NDM-1 plasmid affected 29 patients residing in Jeroen Bosch Hospital (’s-Hertogenbosch, the Netherlands), a 683-bed tertiary teaching hospital. The identified index patient came from Israel for a liver transplantation. The capsule of Klebsiella pneumoniae is composed of extracellular polysaccharides that inhibit the activity of host defense peptides and polymyxins. You may experience chest discomfort due to the coughing as well. Antibiotic resistance (ABR) is one of the biggest threats to global health. 191 of these strains could be sero-typed. Consequently, siderophores are important pathogenicity characteristics of Klebsiella bacteria. Med J Aust . The high economic burden resulting from KPLA is also the concern [9]. Its effects in humans range from harmless to dangerous, depending on the strain of the bacterium, its location Klebsiella pneumoniae is the most significant clinical species of the Klebsiella genus, and also one of the most frequently observed Gram negative opportunistic pathogens in humans (Podschun and Ullmann, 1998; Navon-Venezia et al., 2017). Here, we report the genomic characterization of an unusual Klebsiella pneumoniae, nonsusceptible to all 26 antibiotics tested, that was isolated from a U.S. . Klebsiella pneumoniae is an opportunistic, Gram-negative, rod-shaped bacterium belonging ... importance. 203 (7):300-1. In this study, we performed capsular sero- ... p = 0.022). Contrary to European trends our study showed low antibiotic resistance among K. pneumoniae isolates supporting the hypothesis of absence of successful multidrug-resistant K. pneumoniae clones in the Stockholm area. Klebsiella pneumoniae. [Medline] . The percentage of DM in KPLA patients was as high as 60–78.4 % in previous studies in Taiwan [12, 16, 17, 20]. Rhee C, Kadri SS, Dekker JP, et al; CDC Prevention Epicenters Program. Market garden products can carry several types of microorganisms, and their consumption is the source of many cases of food poisoning. Keywords: ESBL -producing Klebsiella pneumoniae, Urinary tract infection, Clinical impact, Eco-nomic impact 1. In humans, the bacteria are often present in parts of the digestive tract where they do not generally cause problems. Moreover, we compared antimicrobial resistance and relative prevalence of KP and EC (KP/EC-ratio) in different European … High level carbapenem resistance was observed. Infections caused by KPC-producing bacteria can be difficult to treat because fewer antibiotics are effective against them. In such cases, a microbiology laboratory must run tests to determine which antibiotics will treat the infection. What should patients do if they think they have a Klebsiella–related illness? See a healthcare provider. ducing K. pneumoniae requiring hospitalization, and time to adequate antimicrobial therapy are as-sociated with worse clinical and economic outcomes. Learn more here. hvKp is more virulent than classical K. pneumoniae (cKp) and capable of causing community‐acquired infections, often in healthy individuals. Notes: a Significance between bacterial species determined using Kruskal–Wallis test for continuous variables and Pearson chi-squared test or Fisher’s exact test for categorical variables. hvKp is carried in the gastrointestinal tract, which contributes to its spread in the community and healthcare settings. Introduction. K. pneumoniae from the family Enterobacteriaceae, occurs in the human and animal gastrointestinal tract microbiome. In recent years, Klebsiella species have become important pathogens in nosocomial infections. AU - Hines, David W. AU - Spear, Joel B. Klebsiella is a type of bacteria commonly found in nature. Gram-negative, non-motile, capsulated, gas-producing rods found widely in nature and associated with urinary and respiratory infections in humans. E. coli and Klebsiella pneumoniae Species Specific PCR Identification Tests. Many Klebsiella infections are acquired in the hospital setting or in long-term care facilities. He described it as an encapsulated bacillus after isolating the bacterium from the lungs of those who had died from pneumonia. Methods: Clinical isolates of A. baumannii and K. pneumoniae … remains an important cause of severe community-acquired ... economic factors. Increasingly, Klebsiella bacteria have developed antimicrobial resistance, most recently to the class of antibiotics known as carbapenems. Siderophore profile K. pneumoniae can also cause community-acquired urinary … Isolates collected were recovered on MacConkey agar at 35°C and were identified as members of Enterobacteriaceae, and further … Klebsiella pneumoniae liver abscess (KPLA) is an emerging syndrome with the initial cases described in Taiwan in the 1980s. Reyes J, Aguilar AC, Caicedo A. Carbapenem-resistant Klebsiella pneumoniae: microbiology key points for clinical practice. Klebsiella pneumoniae is a gram-negative, lactose-fermenting, non-motile, aerobic rod-shaped bacterium. This paper. Background: Klebsiella pneumoniae is a bacterial species that often causes infections in humans. Introduction. Abstract. Sometimes bacteria like Klebsiella change so that certain antibiotics don’t kill them anymore. The hospital stay was shorter in ALA (7.5 days, IQR 7–8.5) than in PLA (14 days, IQR 9–17). Methods: A cost-of-illness study conducted with a prospective cohort design with hospitalized adults infected by KPC. 57, Issue. Due to the presence of complex impurities, crude glycerol has low value for industry without costly purification. 9, p. 1246. Therefore, it is also necessary to intensify research in identifying and isolating different varieties This genus is commonly found in the intestinal tract and is an opportunistic pathogen that can give rise to bacteremia, pneumonia, urinary … This supports the ambition to reduce infections by 50% by 2021. Read NHS Improvement’s plans to reduce these infections. Patient-level data of any Klebsiella spp. bloodstream infections are reported monthly to Public Health England. Klebsiella spp. data is included in our mandatory surveillance publications from October 2017. The best performance of columns was obtained for inlet bacterial concentrations below 10(6) cells/100 ml. Herein, we analyzed risk factors and prognosis in invasive infections caused by KP versus EC, in an area with low antimicrobial resistance. INTRODUCTION. In 2008, an increase in the prevalence of carbapenem-resistant Klebsiella pneumoniae was noted in a 286-bed tertiary case hospital in Colombia, where 84 patients (32 infected and 52 colonized) had positive cultures. Klebsiella species are a Gram-negative rod shaped bacteria belonging to the Enterobacteriaceae family. Carbapenem use is among the most significant factors favoring the development of carbapenem-resistant enterobacteria, worsening hospital outbreaks, and/or endemics [ 5 , 6 ]. 37 Full PDFs related to this paper. Infections with multi-drug resistant (MDR) bacteria including carbapenem-resistant Klebsiella pneumoniae are emerging worldwide but are difficult to treat with the currently available antibiotic compounds and therefore constitute serious threats to human health. Our case presents a unique example of an adult with signs and symptoms of Purpura Fulminans in the setting of Klebsiella pneumoniae bacteremia and Acetaminophen toxicity. This hospital outbreak started in a surgical ward. New research has found that antibiotic-resistant strains of Klebsiella pneumoniae, an opportunistic pathogen that can cause respiratory and bloodstream infections … Infections by ESKAPE (Enterococcus, S. aureus, K. pneumoniae, A. baumannii, P. aeruginosa, and E. coli) organisms are the leading cause of healthcare-acquired infections worldwide. The Importance of Long-term Acute Care Hospitals in the Regional Epidemiology of Klebsiella pneumoniae Carbapenemase–Producing Enterobacteriaceae. A genus of gram-negative, facultatively anaerobic, rod-shaped bacteria whose organisms arrange singly, in pairs, or short chains. Antimicrobial resistance is a threat to public health globally and leads to an estimated 23,000 deaths annually in the United States alone. A study was designed to characterize nonrepeat isolates of carbapenemase-producing K. pneumoniae obtained from the SMART worldwide surveillance program during 2008 and 2009. Clinical Infectious Diseases, Vol. (8, 9, 10). Photo: Chiara.marraccini/Wikimedia Commons, CC BY 4.0. of Klebsiella pneumoniae isolates could not be carried out. Carbapenemase genes were detected in 33 (33/96, 34.4%), including eight clinical isolates of OXA-181-producing Klebsiella pneumoniae from patients in three different hospitals. And for the simulated PT regimens, the decreasing CFRs (70–75%) were found against the … Vegetables, Klebsiella pneumoniae, Fluorescent Pseudomonas spp., β-Lactamases, Food Safety 1. The antimicrobial resistance profiles and the virulence profiles of these strains vary with the former tagged as notorious [3, 5].Notwithstanding, several clones of these ncKp … Mice were infected intranasally and the bacterial loads in trachea, lung, and spleen homogenates were determined at 24 and 72 h postinfection ( Fig. K. pneumoniae causes hospital-acquired infections. i Abstract Klebsiella pneumoniae and Mycobacterium avium subspecies paratuberculosis (Map) are two important pathogens of cattle causing clinical mastitis (CM) and Johne‘s disease (JD), respectively.

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