Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. A Chinese translation 中文翻译 of this information is available below. Your report will contribute to the TGA's monitoring of these products. Taking fo-ti along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Anti-inflammatory activity of Chinese medicinal vine plants. Avula, B., Joshi, V. C., Wang, Y. H., and Khan, I. Eur.J Pharmacol. View abstract. Park HJ, Zhang N, Park DK. and its processed products on fat accumulation in the liver of mice]. 8-29-2008;128(3):350-358. Covington TR, et al. View abstract. View abstract. Helxine multiflorum (Thunb.) and its isolated bioactive compounds. He Shou Wu (Polygonum multiflorum) by Subhuti Dharmananda, Ph.D., Institute for Traditional Medicine, Portland, Oregon . Fo-ti is a type of laxative called a stimulant laxative. Zhang CZ, Wang SX, Zhang Y, et al. Fo-ti might decrease how quickly the liver breaks down some medications. In animal studies, processed Fo ti also reduced the amount of fat that deposited in the liver and it may protect the liver from damage by toxins such as dry cleaning fluid. Zhang, L., Yang, X., Sun, Z., and Qu, Y. Medications for diabetes (Antidiabetes drugs) interacts with FO-TI. 11-20-2008;120(2):287-290. Zhongguo Zhong.Yao Za Zhi. Yu J, Xie J, Mao XJ, et al. 2010;35(6):612-615. Chen, L. W., Wang, Y. Q., Wei, L. C., Shi, M., and Chan, Y. S. Chinese herbs and herbal extracts for neuroprotection of dopaminergic neurons and potential therapeutic treatment of Parkinson's disease. Hu zhang is commonly used by mouthy for conditions of the heart, liver, and digestive system and to reduce symptoms of menopause. View abstract. He Shou Wu (aka: ho-shou-wu, heshouwu, or shouwu; sometimes mistakenly called fo-ti) is a Chinese herb obtained from the tuberous roots of Polygonum multiflorum. Consumers should stop taking the product and seek medical advice if they experience any of the following symptoms: yellowing of the skin or eyes, dark urine, nausea, vomiting, unusual tiredness, weakness, stomach or abdominal pain and/or loss of appetite. View abstract. Diarrhea can increase the effects of warfarin and increase the risk of bleeding. Gut Liver 2011;5(4):493-9. Learn what scientists have discovered about its potential benefits and risks. The illness was generally self-limited, but fatal instances have been reported in up to 10% of cases. Some medications that can harm the liver include acetaminophen (Tylenol and others), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporanox), erythromycin (Erythrocin, Ilosone, others), phenytoin (Dilantin) , lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), and many others. View abstract. It is also applied to the skin to help speed wound healing. J.Nat.Prod. J Ethnopharmacol 2011;135(2):369-75. J Ethnopharmacol 2006;104:144-8. He Shou Wu is called Polygonum multiflorum and sometimes Fallopia multiflora. Before taking fo-ti, talk to your healthcare provider if you take any medications that are changed by the liver. Polygonum multiflorum, Helxine multiflorum, Pleuroptterus cordatus, Polygonum convolvulus, Polygonum … Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)Interaction Rating: Moderate Be cautious with this combination.Talk with your health provider. Stimulant laxatives speed up the bowels. View abstract. View abstract. View abstract. View abstract. At this time there is not enough scientific information to determine an appropriate range of doses for fo-ti. Fallopia multiflora (Thunberg) Haraldson, synonym Polygonum multiflorum Thunb., is a well-known traditional medicine in several South Asian countries. Nat.Prod.Res 5-20-2007;21(6):487-493. A climbing vine, with a huge, perennial root. J Chromatogr.A 5-19-2006;1115(1-2):64-71. Yao, S., Li, Y., and Kong, L. Preparative isolation and purification of chemical constituents from the root of Polygonum multiflorum by high-speed counter-current chromatography. The appropriate dose of fo-ti depends on several factors such as the user's age, health, and several other conditions. Zhang, Z. G., Lu, T. S., and Yao, Q. Q. [Clinical study on a randomized, double-blind control of Shenwu gelatin capsule in treatment of mild cognitive impairment]. Fatigu… View abstract. View abstract. 2007;6(4):273-281. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using. Failure to do so will lead to regulatory action, which may include the recall and/or cancellation of a product. UK Medicines and Healthcare Products Regulatory Agency. Aliment.Pharmacol.Ther 10-15-2006;24(8):1179-1186. He Shou Wu (Fallopia multiflora) Extract. •. Fallopia multiflora extract was shown to have effects on … This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. It is cultivated in a cool climate. Some medications that are changed by the liver include diclofenac (Cataflam, Voltaren), ibuprofen (Motrin), meloxicam (Mobic), and piroxicam (Feldene); celecoxib (Celebrex); amitriptyline (Elavil); warfarin (Coumadin); glipizide (Glucotrol); losartan (Cozaar); and others. Diabetes medications are also used to lower blood sugar. 1-14-2008;578(2-3):339-348. Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others. Laird AR, Ramchandani N, deGoma EM, et al. Fo-ti is an herb used in traditional Chinese medicine as a longevity tonic. As a consequence, it is a requirement that listed medicines containing Fallopia multiflora for oral use to have the following warning on the product label: 'Warning: Fallopia multiflora may harm the liver in some people. Some medications that are changed by the liver include omeprazole (Prilosec), lansoprazole (Prevacid), and pantoprazole (Protonix); diazepam (Valium); carisoprodol (Soma); nelfinavir (Viracept); and others. Decline in memory and thinking skills that occurs normally with age. CNS.Neurol.Disord.Drug Targets. Some "water pills" that can decrease potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDIURIL, Microzide), and others. 何首乌（亦称多花蓼,Fo ti，Reynoutria multiflora，Chinese fleeceflower root）是一种草药。 市场销售的何首乌适用于头发稀疏，“补血”和各种其他病症。, 澳大利亚规定在列药品中可以使用何首乌。在列药品由产品标签上的“AUST L”数字标识。含有何首乌的在列药品可以从一系列供应商，包括通过保健食品商店和传统中医执业者购买。, 极少数情况下，何首乌与低风险度的肝损伤有关。因此，澳大利亚治疗产品管理局要求含有何首乌的在列口服药品在产品标签上提供以下警告："警告：何首乌可能导致一些人的肝损伤。应在健康保健专业人士监督下使用。", 澳大利亚治疗产品管理局（TGA）在2008年至2018年期间收到9例消费者服用含有何首乌药品肝损伤的报告。对于这些报告， 我局已启动针对所涉及的产品以及何首乌的安全调查。 我局将会公布调查结果。可能采取的监管行动包括：取消任何安全性不可接受的产品注册资格，或改变对在列药品允许使用成分的要求。, 此外，目前进行对何首乌的安全调查发现一些由传统中医执业者出售的产品没有按要求提供安全警告，这些产品 已被召回。, 如果出现以下任何症状，消费者应停止服用该产品并寻求医疗建议：皮肤或眼睛发黄，尿色深，恶心，呕吐，异常疲倦，虚弱，胃痛或腹痛和/或食欲不振。, 健康专业人士应注意，在极少数情况下，一些非西药辅助药物可能导致一些人的肝损害。 在治疗出现肝损症状的患者时，健康专业人士应考虑肝损是否与辅助药物有关。, 提醒厂商有义务遵守 允许成分决定 的要求。违反要求将导致可能包括召回产品和/或取消产品注册资格的监管行动。, 治疗产品管理局鼓励消费者和健康专业人士报告药物或疫苗的问题。您的报告将有助于我们对这些产品的监控。, 治疗产品管理局无法就个人的健康状况提供建议。如果您担心可能与药物或疫苗相关的不良反应事件，强烈建议您向健康专业人士咨询。, The Therapeutic Goods Administration is part of the Health Products Regulation Group, Australian Government Department of Health, Reporting adverse events involving medicines, vaccines or medical devices, Report an issue with packaging or storage of a medicine, Help us promote adverse event reporting: promotional resources kit, Early Warning System: consumer questions and answers, Early Warning System: health professional questions and answers, Black Triangle Scheme: Information for sponsors, Database of Adverse Event Notifications (DAEN), Information for consumers and health professionals, Travelling with medicines and medical devices, Buying medicines and medical devices online, Medicinal cannabis: importation and the traveller's exemption, Accessing medicines during a medicines shortage, Transvaginal (urogynaecological) surgical mesh hub, MedSearch | Medicine information search app, Medicine shortages: Information for Health Professionals, Accessing medicines during a medicine shortage, Accessing e-cigarettes containing nicotine, Labelling changes: information for health professionals, Registration of medicines for the medical termination of early pregnancy, Prescribing medicines in pregnancy database, Medicine Shortages Information Initiative, Fast track approval pathways for prescription medicines, Breast implant associated-anaplastic large cell lymphoma (BIA-ALCL), Changes to labelling and regulation of hard surface disinfectants (commencing 1 April 2019), Information for medical practitioners on pending up-classification of surgical mesh devices, Advice about medical devices for health professionals, Regulation of stem cell treatments: information for practitioners, Australian Adverse Drug Reactions Bulletin, Medical device incident reporting & investigation scheme (IRIS) articles, Health professional information & education, Health professional educational materials, Overview of applying for market authorisation, Overview of medical devices and IVD regulation, Useful resources for business and researchers, How therapeutic goods are regulated in Australia, Australian Regulatory Guidelines for Prescription Medicines, Forms for complementary medicine sponsors, Australian Regulatory Guidelines for Biologicals, Regulation of platelet-rich plasma (PRP), platelet-rich fibrin (PRF) and conditioned serum, Forms for the blood and blood components industry, Disinfectants, sterilants and sanitary products, Scheduling committees meeting dates and decisions timeframes, Report a perceived breach or questionable practices, Consent to import, supply or export goods that do not comply with standards, Cancellation requested by the sponsor - regulatory actions, Failure to pay annual charges - regulatory actions, Information & notices about TGA fees & payments, TGA Business services: getting started with the TGA, TGA Business services - how to use the site, Links to international agencies & organisations, Medicines and Medical Devices Regulation Review, recalling its Fusion Hair Tonic and Oriental Botanicals Hairpro products, Chinese translation 中文翻译 of this information, report problems with medicines or vaccines. 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